The Crew won 3-0, with Lucas Zelarayan marking two goals and Derrick Etienne scoring one.
This is the second MLS Cup crown for the Crew, which also won in 2008.
Columbus’ Pedro Santos and Darlington Nagbe missed the match after testing positive for Covid-19, MLS.com reported.
Major League Soccer suspended its season in March due to the coronavirus pandemic and resumed play in July.
Read More:Columbus Crew beats Seattle Sounders to win a second MLS championship